Inaba M
Gan To Kagaku Ryoho. 1982 Feb;9(2):165-76.
General discussions on the drug resistance of cancer cells were made from various points of view: (1) drug resistance as an unhereditary phenotype, (2) changes in the cell population during drug treatment, (3) acquired resistance and natural resistance, (4) general concepts on biochemical and pharmacological mechanisms for drug resistance, (5) common mechanism for concurrent resistance to DNA-intercalators and vinca-alkaloids, and (6) collateral sensitivity on a cellular basis.
(1) 耐药性作为一种非遗传性表型；(2) 药物治疗期间细胞群体的变化；(3) 获得性耐药和天然耐药；(4) 耐药性生化和药理机制的一般概念；(5) 对DNA嵌入剂和长春花生物碱同时耐药的共同机制；以及(6) 基于细胞的旁系敏感性。
