González-Gómez A, García-Barreto D, Gamio Capestany F, Hernández-Cañero A, Fong Chi S
Cor Vasa. 1982;24(6):422-8.
Plasma renin activity (PRA) and systolic time intervals (STI), including total electromechanical systole (QS2), left ventricular ejection time (LVET), pre-ejection period (PEP) and isovolumetric contraction time (ICT), were measured in patients with borderline hypertension (n = 23) before and after oral treatment with atenolol and propranolol. Both beta blockers caused a similar fall in blood pressure and heart rate (P less than 0.001). QS2, PEPc and PEP/LVET values did not change after treatment. Propranolol prolonged ICT (p less than 0.001) and reduced LVET (p less than 0.001). No significant changes were detected in PRA after atenolol while a reduction was found after treatment with propranolol (p less than 0.001). No relationship was found between PRA and STI, however a linear correlation was recorded between systolic pressure and PRA (r = 0,91; p less than 0.01) before beta-blockade. These results suggest that: a) only beta 2-adrenoceptors are involved in the release of renin; and b) the effect of beta-blockers on STI follows a reduction of blood pressure and heart rate which in turn affect afterload.
在临界高血压患者（n = 23）口服阿替洛尔和普萘洛尔治疗前后，测量其血浆肾素活性（PRA）和收缩期时间间期（STI），包括总电机械收缩期（QS2）、左心室射血时间（LVET）、射血前期（PEP）和等容收缩期（ICT）。两种β受体阻滞剂均使血压和心率出现相似程度的下降（P < 0.001）。治疗后QS2、PEPc和PEP/LVET值未发生变化。普萘洛尔使ICT延长（P < 0.001），LVET缩短（P < 0.001）。阿替洛尔治疗后PRA未检测到显著变化，而普萘洛尔治疗后PRA降低（P < 0.001）。未发现PRA与STI之间存在关联，然而在β受体阻滞剂治疗前，收缩压与PRA之间记录到线性相关性（r = 0.91；P < 0.01）。这些结果表明：a）只有β2 - 肾上腺素能受体参与肾素释放；b）β受体阻滞剂对STI的影响是血压和心率降低的结果，而这又反过来影响后负荷。
