Lehner J P, Simon A, Kehder A, Weiss Y, Tzincoca C, Safar M
Arch Mal Coeur Vaiss. 1978 Oct;71(10):1107-12.
Cardiac output (isotopic dilution method) and systolic time intervals were studied in 11 sustained and 8 borderline essential hypertensive patients, before and after intravenous administration of atenolol, a potent beta-blocking agent. Atenolol decreased significantly (p less than 0.01) cardiac output and heart rate. In borderline hypertensives, the preejection periods were significantly reduced. Atenolol prolonged the preejection periods more significantly (p less than 0.01) in borderline than in permanent hypertensives. Non invasive hemodynamic technics enabled the cardiac performance to be evaluated in hypertensives and the contribution of neurogenic factors in borderline hypertension to be estimated.
采用同位素稀释法对11例持续性原发性高血压患者和8例临界性原发性高血压患者在静脉注射强效β受体阻滞剂阿替洛尔前后的心输出量和收缩期时间间期进行了研究。阿替洛尔显著降低了心输出量和心率（p<0.01）。在临界性高血压患者中，射血前期显著缩短。阿替洛尔使临界性高血压患者的射血前期延长得比持续性高血压患者更显著（p<0.01）。无创血流动力学技术能够评估高血压患者的心脏功能，并估计神经源性因素在临界性高血压中的作用。
