多中心临床试验：布拉德福德·希尔的贡献及一些后续进展。

Multicentre clinical trials: Bradford Hill's contributions and some subsequent developments.

作者信息

Fleiss J L

出版信息

Stat Med. 1982 Oct-Dec;1(4):353-9. doi: 10.1002/sim.4780010413.

Abstract

Most large comparative trials of therapeutic agents are now conducted as multicentre studies. Some of the major studies designed by Bradford Hill were also multicentre, and his methods of design and conduct remain valid today, even though improved methods for analysing the data have appeared subsequently.

摘要

目前，大多数治疗药物的大型对比试验都是作为多中心研究开展的。布拉德福德·希尔设计的一些主要研究也是多中心的，尽管后来出现了改进的数据分析法，但他的设计和实施方法至今仍然有效。