Holland W W, Breeze E, Swan A V
Stat Med. 1982 Oct-Dec;1(4):361-8. doi: 10.1002/sim.4780010414.
The principles and historical development of clinical trials are outlined briefly. Some issues that extend the basic philosophy first put forward by Sir Austin Bradford Hill 40 years ago and that will need consideration in the future application of clinical trials are discussed.
本文简要概述了临床试验的原则和历史发展。讨论了一些扩展了40年前奥斯汀·布拉德福德·希尔爵士首次提出的基本理念、且在未来临床试验应用中需要考虑的问题。
