Takemoto L J, Hansen J S, Horwitz J
Curr Eye Res. 1982;2(12):849-54. doi: 10.3109/02713688209020021.
Treatment of normal lens homogenates with trypsin results in the production of polypeptides of approximately 4,000 and 8,000 daltons. Peptide maps of these components are very similar to poly-peptides of comparable molecular weight found only in cataracts with brunescent and opaque nuclei. Together, these results demonstrate that putative proteolysis products produced in vivo during human cataractogenesis can be mimiced in vitro by the addition of exogeneous proteases to the normal lens homogenate.
用胰蛋白酶处理正常晶状体匀浆会产生分子量约为4000和8000道尔顿的多肽。这些成分的肽图与仅在具有棕色和不透明核的白内障中发现的分子量相当的多肽非常相似。这些结果共同表明，在人类白内障形成过程中体内产生的假定蛋白水解产物可以通过向正常晶状体匀浆中添加外源蛋白酶在体外模拟出来。
