Betow C
J Laryngol Otol Suppl. 1982;5:1-28.
Since I introduced the homograft transplantation en bloc in 1959, more than 2,400 patients with chronic middle-ear inflammation and the conditions resulting from an old radical operation have been operated upon. Different kinds of chemical solution for the conservation of the homograft have been used, and experience has shown that the best solution is a combination of Cialit 1:5,000 and formaldehyde 4 per cent, pH. 7.2. The indications for a homograft transplant have to be very precise, and we have divided the indications into two groups: In the first group, belonging to routine ear surgery, we can use homograft fascia, perichondrium, dura, ossicles and cartilage in the same way as in autografts. The second group is indicated when a larger part of the middle ear is destroyed. The healing process and function of the middle ear after homograft transplantation depend on correct indications, on preparation of the middle ear, on the correct fitting of the transplant, and on careful treatment after the transplantation. By using homografts in routine surgery of the middle ear, the structural and functional results are equivalent to those of autografts. In the second group, in which a large part of the middle ear is destroyed, or in which the condition resulting from a radical operation is achieved by an immediate fresh operation on the middle ear, the healing and functional results are much better than with patients after an old radical operation.
自1959年我首次引入整块同种异体移植术以来，已有超过2400例患有慢性中耳炎症以及因既往根治性手术导致相关病症的患者接受了手术治疗。我们使用了不同种类的化学溶液来保存同种异体移植物，经验表明，最佳溶液是1:5000的西阿利特（Cialit）和4%的甲醛的混合溶液，pH值为7.2。同种异体移植的适应证必须非常精确，我们将适应证分为两组：第一组属于常规耳部手术，我们可以像使用自体移植物一样使用同种异体筋膜、软骨膜、硬脑膜、听小骨和软骨。第二组适用于中耳大部分结构被破坏的情况。同种异体移植术后中耳的愈合过程和功能取决于正确的适应证、中耳的准备情况、移植物的正确适配以及术后的精心治疗。在中耳常规手术中使用同种异体移植物，其结构和功能结果与自体移植物相当。在第二组中，中耳大部分结构被破坏，或者通过对中耳立即进行新的手术来改善既往根治性手术导致的状况，其愈合和功能结果比接受过既往根治性手术的患者要好得多。
