Lindstöm P
Acta Biol Med Ger. 1982;41(12):1185-90.
5-Hydroxytryptamine (5-HT) and dopamine were found to inhibit glucose-induced insulin release and 45Ca2+ net uptake in islets microdissected from ob/ob-mice. Dopamine was more potent than 5-HT. L-DOPA, the precursor of dopamine, had an effect similar to that of dopamine and this effect was reduced by benserazide. L-5-hydroxytryptophan, the precursor of 5-HT, potentiated glucose-induced insulin release and stimulated 45Ca2+ uptake. This effect was also blocked by benserazide. It is concluded that dopamine is a stronger inhibitor than 5-HT and that the different actions of 5-HTP and L-DOPA might be explained by this difference in the magnitude of inhibition.
研究发现，5-羟色胺（5-HT）和多巴胺可抑制从ob/ob小鼠分离的胰岛中葡萄糖诱导的胰岛素释放及45Ca2+净摄取。多巴胺的作用比5-HT更强。多巴胺的前体左旋多巴（L-DOPA）具有与多巴胺类似的作用，且此作用可被苄丝肼减弱。5-HT的前体L-5-羟色氨酸可增强葡萄糖诱导的胰岛素释放并刺激45Ca2+摄取。此作用也可被苄丝肼阻断。由此得出结论，多巴胺是比5-HT更强的抑制剂，5-羟色氨酸（5-HTP）和L-多巴（L-DOPA）的不同作用可能可用这种抑制强度的差异来解释。
