[顺铂对多形核白细胞收缩系统的影响]
[Effects of cis-platin on the contractile system of polymorphonuclear leukocytes].
作者信息
Fumarulo R, De Rinaldis P, Riccardi S, Giordano D
出版信息
G Batteriol Virol Immunol. 1982 Jul-Dec;75(7-12):224-32.
PMID:6765201
Abstract
The effects of cis-Platinum, a new antitumor drug, on guinea pig polymorphonuclear functions related to subplasmalemmal fibrillar structures, were investigated. The compound markedly decreased chemotaxis. Zymosan particles engulfment and degranulation. The depression of these leucocyte activities adds to the already known drug induced myelotoxicity .
摘要
研究了一种新型抗肿瘤药物顺铂对豚鼠多形核白细胞与质膜下纤维状结构相关功能的影响。该化合物显著降低了趋化性、酵母聚糖颗粒吞噬作用和脱粒作用。这些白细胞活性的降低加剧了已知的药物诱导的骨髓毒性。
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