Fumarulo R, Riccardi S, Pantaleo R, Coluccia M, Giordano D, Aresta M
Int J Cancer. 1985 Jun 15;35(6):777-80. doi: 10.1002/ijc.2910350613.
The effects of cis-diamminedichloroplatinum (II) (cisplatin), a drug used in cancer chemotherapy, on the oxidative metabolism, endocytosis, chemotaxis and exocytosis of guinea-pig polymorphonuclear leukocytes were studied. All these functions were negatively influenced, but the same effect (50% inhibition) was observed at different drug concentrations (3 X 10(-5) M for chemotaxis, 10(-4) M for O2 consumption by FMLP and beta-glucuronidase release, 10(-3) M for O2 consumption by PMA and for zymosan engulfment). The effects of the drug can be explained by its ability to bind to membrane proteins, essentially to -SH groups.
研究了用于癌症化疗的顺二氯二氨铂（II）（顺铂）对豚鼠多形核白细胞氧化代谢、内吞作用、趋化性和胞吐作用的影响。所有这些功能均受到负面影响，但在不同药物浓度下观察到相同的效果（50%抑制）（趋化性为3×10⁻⁵ M，FMLP刺激的耗氧量和β-葡萄糖醛酸酶释放为10⁻⁴ M，PMA刺激的耗氧量和酵母聚糖吞噬为10⁻³ M）。该药物的作用可通过其与膜蛋白（主要是-SH基团）结合的能力来解释。
