辣椒素可使通过免疫组织化学检测到的大鼠脊髓背角中胆囊收缩素样免疫反应性减少，但不会使通过放射免疫测定法测得的该免疫反应性减少。

Capsaicin depletes CCK-like immunoreactivity detected by immunohistochemistry, but not that measured by radioimmunoassay in rat dorsal spinal cord.

作者信息

Schultzberg M, Dockray G J, Williams R G

出版信息

Brain Res. 1982 Mar 4;235(1):198-204. doi: 10.1016/0006-8993(82)90213-x.

DOI:10.1016/0006-8993(82)90213-x

Abstract

In rats treated neonatally with capsaicin there were significant reductions in substance P measured by radioimmunoassay in dorsal spinal cord, spinal ganglia, and coeliac ganglia, but concentrations of cholecystokinin octapeptide (CCK8) measured by radioimmunoassay were not decreased. However, immunohistochemical studies using antisera to both substance P and CCK8, respectively, demonstrated decreased immunoreactive material in the dorsal horn of the spinal cord. The nature of the material localized by CCK8 antiserum in immunohistochemistry remains to be resolved.

摘要

在用辣椒素对新生大鼠进行处理后，通过放射免疫测定法测得，其背脊髓、脊髓神经节和腹腔神经节中的P物质显著减少，但通过放射免疫测定法测得的八肽胆囊收缩素（CCK8）浓度并未降低。然而，分别使用针对P物质和CCK8的抗血清进行的免疫组织化学研究表明，脊髓背角中的免疫反应性物质减少。免疫组织化学中由CCK8抗血清定位的物质的性质仍有待确定。

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