Marley P D, Nagy J I, Emson P C, Rehfeld J F
Brain Res. 1982 Apr 29;238(2):494-8. doi: 10.1016/0006-8993(82)90130-5.
The distribution of cholecystokinin (CCK) and gastrin-like immunoreactivities in rat spinal cord and spinal roots was studied with two sequence-specific radioimmunoassays. No gastrin was found in the cord or in spinal roots or sensory ganglia, however CCK was present at all levels of the cord and was concentrated in the dorsal horn. No CCK was found in sensory roots. Neonatal capsaicin treatment had no effect on ventral cord CCK and caused a small increase in dorsal cord levels. Neither dorsal rhizotomy nor combined dorsal and ventral rhizotomy affected CCK levels in either dorsal or ventral cord. These results indicate that most of the CCK in the rat spinal cord is not present in the terminals of primary afferent fibers.
采用两种序列特异性放射免疫分析法研究了大鼠脊髓和脊神经根中胆囊收缩素（CCK）和胃泌素样免疫反应性的分布。在脊髓、脊神经根或感觉神经节中未发现胃泌素，但在脊髓的各个节段均存在CCK，且集中于背角。在感觉神经根中未发现CCK。新生大鼠辣椒素处理对脊髓腹侧CCK无影响，但使脊髓背侧水平略有升高。背根切断术和背根与腹根联合切断术均不影响脊髓背侧或腹侧的CCK水平。这些结果表明，大鼠脊髓中的大多数CCK不存在于初级传入纤维的终末。
