Van de Kar L D, Wilkinson C W, Skrobik Y, Brownfield M S, Ganong W F
Brain Res. 1982 Mar 11;235(2):233-43. doi: 10.1016/0006-8993(82)91003-4.
Data from previous experiments in rats indicate that release of serotonin in the central nervous system increases renin and corticosterone secretion. To determine which serotonergic neurons are involved, lesions of the dorsal or median raphe nuclei were produced by local injections of 5,7-dihydroxytryptamine (5,7-DHT) in rats, and 2 weeks later, the renin responses to parachloroamphetamine (PCA) were determined. Plasma corticosterone was also measured. PCA produced significant increases in plasma renin activity and plasma corticosterone in sham-lesioned animals and animals with median raphe lesions. The plasma corticosterone response to PCA was also normal in rats with dorsal raphe lesions but the renin response was significantly reduced. The data support the hypothesis that serotonergic neurons in the dorsal raphe nucleus are part of a neural pathway mediating increased renin secretion, and that the stimulatory effect of serotonin on corticosterone secretion is mediated by a different pathway.
先前在大鼠身上进行的实验数据表明，中枢神经系统中血清素的释放会增加肾素和皮质酮的分泌。为了确定哪些血清素能神经元参与其中，通过在大鼠体内局部注射5,7 - 二羟基色胺（5,7 - DHT）对背侧或中缝核进行损伤，2周后，测定对对氯苯丙胺（PCA）的肾素反应。同时也测量了血浆皮质酮。在假损伤动物和中缝核损伤动物中，PCA使血浆肾素活性和血浆皮质酮显著增加。背侧中缝核损伤大鼠对PCA的血浆皮质酮反应也正常，但肾素反应显著降低。这些数据支持以下假设：背侧中缝核中的血清素能神经元是介导肾素分泌增加的神经通路的一部分，并且血清素对皮质酮分泌的刺激作用是由不同的通路介导的。
