Van de Kar L D, Karteszi M, Bethea C L, Ganong W F
Neuroendocrinology. 1985 Nov;41(5):380-4. doi: 10.1159/000124205.
In previous studies we obtained evidence that serotonin release by p-chloroamphetamine (PCA) causes an increase in corticosterone secretion but that this effect is not mediated via the raphe nuclei in the midbrain. In contrast, PCA-induced prolactin secretion was abolished by dorsal raphe lesions. In the present study, posterolateral cuts which interrupted caudal inputs to the hypothalamus attenuated the effect of PCA on plasma prolactin but did not block the PCA-induced increase in plasma corticosterone levels. Large lesions of the mediobasal hypothalamus produced a significant reduction of plasma corticosterone concentration but did not completely prevent the effect of PCA on corticosterone secretion. Hypophysectomy performed 24 h before sacrifice caused a marked decrease in plasma corticosterone levels but did not completely abolish the effect of PCA. These results suggest that PCA also stimulates corticosterone secretion via a direct action on the adrenal gland. The lesions in the mediobasal hypothalamus caused an increase in plasma prolactin concentration, and in these rats, PCA suppressed rather than stimulated prolactin secretion. This suggests that the known weak dopamine agonist activity of PCA is exposed when the effects of serotonin release in the brain are eliminated.
在先前的研究中，我们获得的证据表明，对氯苯丙胺（PCA）释放血清素会导致皮质酮分泌增加，但这种作用并非通过中脑的中缝核介导。相反，背侧中缝核损伤消除了PCA诱导的催乳素分泌。在本研究中，中断下丘脑尾部输入的后外侧切口减弱了PCA对血浆催乳素的作用，但并未阻断PCA诱导的血浆皮质酮水平升高。下丘脑内侧基底部的大面积损伤导致血浆皮质酮浓度显著降低，但并未完全阻止PCA对皮质酮分泌的作用。在处死前24小时进行垂体切除术导致血浆皮质酮水平显著下降，但并未完全消除PCA的作用。这些结果表明，PCA还通过对肾上腺的直接作用刺激皮质酮分泌。下丘脑内侧基底部的损伤导致血浆催乳素浓度升高，在这些大鼠中，PCA抑制而非刺激催乳素分泌。这表明，当大脑中血清素释放的作用被消除时，PCA已知的弱多巴胺激动剂活性就会显现出来。
