Diana J N, Fleming B P, Bairnsfather L E
Int J Microcirc Clin Exp. 1982;1(4):393-407.
Accurate, quantitative information relating to hydraulic conductivity (Lp) of the capillary wall in any organ of tissue is essential as the first step toward understanding fluid homeostasis. Any perturbation which permanently alters fluid balance will ultimately lead to death and destruction of tissues in the living organism. This report summarizes some recent information relating to Lp measurements in single capillary and whole organ experiments. It is shown that the single capillary and whole organ methods do not yield similar quantitative information and some possible reasons for this are discussed. It is hypothesized that capillary membrane permeability is governed by dynamic processes which may change in response to both the metabolic requirements of the organ tissue cells and overall metabolic homeostasis of the organism. It follows from this hypothesis that fluid balance in tissues is a passive process determined solely by the Starling forces, the functional significance of which is to provide an aqueous medium to aid the diffusion of nutrient substrate from blood to tissue cells.
有关任何组织器官中毛细血管壁水力传导率（Lp）的准确、定量信息，对于迈向理解液体稳态的第一步至关重要。任何永久性改变液体平衡的干扰最终都会导致活生物体组织的死亡和破坏。本报告总结了一些与单根毛细血管和全器官实验中Lp测量相关的最新信息。结果表明，单根毛细血管法和全器官法并未得出相似的定量信息，并讨论了其中一些可能的原因。据推测，毛细血管膜通透性受动态过程支配，这些过程可能会因器官组织细胞的代谢需求和生物体的整体代谢稳态而发生变化。基于这一假设可以得出，组织中的液体平衡是一个仅由斯塔林力决定的被动过程，其功能意义在于提供一种水性介质，以帮助营养底物从血液扩散到组织细胞。
