Curry F R, Huxley V H
Int J Microcirc Clin Exp. 1982;1(4):381-91.
We have selected whole organ and single capillary data to examine the hypothesis that a network of fibrous molecules on the surface of the endothelial cell determines the selectivity and specific hydraulic conductivity of the walls of capillary blood vessels. Fibers with a 0.3-0.6 nm radius, occupying from 3 to 5% of the pathway volume, account for the albumin reflection coefficient and the specific hydraulic conductivity of transcapillary channels in the capillaries of frog mesentery and mammalian hindlimb, heart and lung. Similar fiber dimensions account for the selectivity of fenestrated capillaries of dog gastric wall to albumin, but they predict a specific hydraulic conductivity for this organ which is smaller than the observed value. Plasma proteins are required to maintain the integrity of the size-limiting structures in the capillary wall. The data from Ringer perfused vessels conform to the hypothesis that the fibers condense into a coarser network when protein is removed from the perfusate.
我们选择了全器官和单个毛细血管的数据，以检验以下假设：内皮细胞表面的纤维分子网络决定了毛细血管壁的选择性和特定水力传导率。半径为0.3 - 0.6纳米的纤维占据通道体积的3%至5%，这解释了青蛙肠系膜以及哺乳动物后肢、心脏和肺部毛细血管中白蛋白反射系数和跨毛细血管通道的特定水力传导率。类似的纤维尺寸解释了狗胃壁有孔毛细血管对白蛋白的选择性，但它们预测该器官的特定水力传导率小于观测值。血浆蛋白是维持毛细血管壁大小限制结构完整性所必需的。用林格氏液灌注血管的数据符合以下假设：当从灌注液中去除蛋白质时，纤维会凝聚成更粗的网络。
