Nestrud R M, Hill D E, Arrington R W, Beard A G, Dungan W T, Lau P Y, Norton J B, Readinger R I
Dev Pharmacol Ther. 1980;1(2-3):125-36.
23 premature infants were placed on a randomized double-blind study to evaluate the effectiveness of indomethacin in closing a patent ductus arteriosus. Infants received 0.2 mg/kg indomethacin or placebo by gavage. In the treatment group, 7 patients responded out of a total of 12, while in the placebo group, 2 responded out of a total of 11. Indomethacin plasma levels were obtained in 6 patients in the treatment group. Plasma levels showed marked variability in peak level (60-3,100 ng/ml), time to peak level (0.5-6 h) and t1/2 (1 to greater than 24 h).
23名早产儿被纳入一项随机双盲研究，以评估吲哚美辛关闭动脉导管未闭的有效性。婴儿通过管饲法接受0.2mg/kg吲哚美辛或安慰剂。治疗组12名患者中有7名有反应，而安慰剂组11名患者中有2名有反应。治疗组6名患者测定了吲哚美辛血浆水平。血浆水平在峰值水平（60 - 3100ng/ml）、达到峰值水平的时间（0.5 - 6小时）和半衰期（1至大于24小时）方面显示出显著差异。
