Scarpignato C, Tirelli F, Starcich R, Bertaccini G
Horm Res. 1981;15(4):228-36. doi: 10.1159/000179461.
The effect of acute and chronic cimetidine administration on glucose tolerance and insulin secretion was studied in healthy male volunteers. Cimetidine was administered intravenously (4 mg X kg-1 followed by 0.7 mg X kg-1 X h-1) in acute studies and by oral route (1 g/die for 4 weeks) in long-term studies. Oral (100 g) or intravenous (0.5 g X kg-1) glucose was used as a stimulus for insulin secretion in both studies. Neither acute nor chronic cimetidine administration modified insulin secretion and glucose tolerance. These data are consistent with the idea that H2-receptors are not involved in the insulinogenic effect of glucose.
在健康男性志愿者中研究了急性和慢性给予西咪替丁对葡萄糖耐量和胰岛素分泌的影响。在急性研究中，静脉注射西咪替丁（4 mg·kg⁻¹，随后以0.7 mg·kg⁻¹·h⁻¹的速度给药）；在长期研究中，通过口服途径给药（1 g/天，持续4周）。在两项研究中，均使用口服（100 g）或静脉注射（0.5 g·kg⁻¹）葡萄糖作为胰岛素分泌的刺激物。急性或慢性给予西咪替丁均未改变胰岛素分泌和葡萄糖耐量。这些数据与H2受体不参与葡萄糖的促胰岛素分泌作用这一观点一致。
