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Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.

作者信息

Mangold B L, Hanna P E

出版信息

J Med Chem. 1982 Jun;25(6):630-8. doi: 10.1021/jm00348a005.

DOI:10.1021/jm00348a005
PMID:6765899
Abstract
摘要

相似文献

1
Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides.
J Med Chem. 1982 Jun;25(6):630-8. doi: 10.1021/jm00348a005.
2
Arylhydroxamic acid bioactivation via acyl group transfer. Structural requirements for transacylating and electrophile-generating activity of N-(2-fluorenyl)hydroxamic acids and related compounds.通过酰基转移实现芳基异羟肟酸的生物活化。N-(2-芴基)异羟肟酸及相关化合物的转酰化和亲电试剂生成活性的结构要求。
J Med Chem. 1982 Jul;25(7):842-6. doi: 10.1021/jm00349a015.
3
Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase.N-（苯基烷基）乙酰氧肟酸作为N-芳基氧肟酸N，O-酰基转移酶潜在底物的合成与评价
J Med Chem. 1982 Oct;25(10):1189-92. doi: 10.1021/jm00352a018.
4
Suicide inactivation of hamster hepatic arylhydroxamic acid N,O-acyltransferase. A selective probe of N-acetyltransferase multiplicity.仓鼠肝脏芳基异羟肟酸N,O-酰基转移酶的自杀失活。N-乙酰转移酶多样性的选择性探针。
Mol Pharmacol. 1982 Jan;21(1):159-65.
5
Mechanism-based inactivation of N-arylhydroxamic acid N,O-acyltransferase by 7-substituted-N-hydroxy-2-acetamidofluorenes.7-取代-N-羟基-2-乙酰氨基芴对N-芳基异羟肟酸N,O-酰基转移酶的基于机制的失活作用
J Med Chem. 1985 Jan;28(1):18-24. doi: 10.1021/jm00379a005.
6
Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissue and species differences, other acyl donors, and arylhydroxamic acid-dependent acyltransferases.N-羟基-3,2'-二甲基-4-氨基联苯及几种致癌性N-羟基芳胺的乙酰辅酶A依赖性代谢活化与组织和物种差异、其他酰基供体以及芳基异羟肟酸依赖性酰基转移酶的关系
Carcinogenesis. 1986 Jun;7(6):919-26. doi: 10.1093/carcin/7.6.919.
7
N-arylhydroxamic acid N,O-acyltransferase. Positional requirements for the substrate hydroxyl group.N-芳基异羟肟酸N,O-酰基转移酶。底物羟基的位置要求。
J Med Chem. 1983 Dec;26(12):1780-4. doi: 10.1021/jm00366a026.
8
Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase.从纯合快速乙酰化近交仓鼠中纯化肝多态性芳胺N-乙酰基转移酶：与多态性N-羟基芳胺-O-乙酰基转移酶相同。
Cancer Res. 1990 Dec 15;50(24):7942-9.
9
The purification of rat liver arylhydroxamic acid N,O-acyltransferase.大鼠肝脏芳基异羟肟酸N,O-酰基转移酶的纯化
J Biol Chem. 1984 Oct 10;259(19):12128-34.
10
Substituent effects on the bioactivation of 2-(N-hydroxyacetamido)fluorenes by N-arylhydroxamic acid N,O-acyltransferase.N-芳基异羟肟酸N,O-酰基转移酶对2-(N-羟基乙酰胺基)芴生物活化的取代基效应
J Med Chem. 1985 Oct;28(10):1453-60. doi: 10.1021/jm00148a014.

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Subcellular Protein Labeling by a Spatially Restricted Arylamine N-Acetyltransferase.亚细胞内蛋白质的空间限制芳基胺 N-乙酰转移酶标记。
ACS Chem Biol. 2018 Aug 17;13(8):1932-1937. doi: 10.1021/acschembio.8b00178. Epub 2018 Jun 14.
2
Formation of N-hydroxy-N-arylacetamides from nitroso aromatic compounds by the mammalian pyruvate dehydrogenase complex.哺乳动物丙酮酸脱氢酶复合物由亚硝基芳香族化合物形成N-羟基-N-芳基乙酰胺。
Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):783-90. doi: 10.1042/bj2900783.