Spratt J S, Adcock R A, Muskovin M, Sherrill W, McKeown J
Cancer Res. 1980 Feb;40(2):256-60.
A 35-year-old man was treated for pseudomyxoma peritonei by surgery and by thermal infusion and chemotherapy with a machine designed specifically for the treatment of cancers of serosal surfaces. After extensive abdominal resection and closure, the patient's peritoneal cavity was instilled with 2.5 liters of 5% lactated Ringer's solution. He was then attached to hyperthermic perfusion system which elevated the i.p. temperature by warming (to 42 degrees) and recirculating the effusion solution. When the 42 degrees i.p. temperature was attained (after 1.5 hr), chemotherapy was added to the recirculating effusion. A second procedure followed 8 days later. The patient's postoperative course was uneventful except for minor pulmonary atelectasis with bacteremia. Hyperthermic perfusion was tolerated well and was evaluated as safe for intracavitary cancer treatment.
一名35岁男性因腹膜假黏液瘤接受了手术治疗，并使用专门设计用于治疗浆膜表面癌症的机器进行热灌注和化疗。在进行广泛的腹部切除和缝合后，向患者的腹腔内注入了2.5升5%的乳酸林格氏液。然后将他连接到热灌注系统，该系统通过加热（至42摄氏度）和循环渗出液来提高腹腔内温度。当腹腔内温度达到42摄氏度时（1.5小时后），将化疗药物加入循环的渗出液中。8天后进行了第二次手术。除了伴有菌血症的轻微肺不张外，患者的术后过程顺利。热灌注耐受性良好，被评估为对腔内癌症治疗安全。
