• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.

作者信息

Elshourbagy N A, Guzelian P S

出版信息

J Biol Chem. 1980 Feb 25;255(4):1279-85.

PMID:6766445
Abstract
摘要

相似文献

1
Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.从孕烯醇酮-16α-腈处理的大鼠中分离、纯化和鉴定一种新型肝细胞色素P-450
J Biol Chem. 1980 Feb 25;255(4):1279-85.
2
Pregnenolone-16alpha-carbonitrile-inducible cytochrome P450 in rat liver.孕烯醇酮-16α-腈诱导的大鼠肝脏细胞色素P450
Res Commun Chem Pathol Pharmacol. 1976 Nov;15(3):553-62.
3
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl.2,3',4,4',5,5'-六氯联苯对大鼠肝微粒体细胞色素P-450的诱导作用
Biochem Pharmacol. 1983 Jul 15;32(14):2269-79. doi: 10.1016/0006-2952(83)90237-x.
4
The effect of phenobarbital, 3-methylcholanthrene, and pregnenolone-16 alpha-carbonitrile on the N-demethylation and O-de-ethylation of [6-H3]ethylmorphine.苯巴比妥、3-甲基胆蒽及孕烯醇酮-16α-腈对[6-H³]乙基吗啡N-去甲基化和O-去乙基化的影响。
Drug Metab Dispos. 1981 Sep-Oct;9(5):483-4.
5
The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16 alpha-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450.苯巴比妥、3-甲基胆蒽、3,4-苯并芘和孕烯醇酮-16α-腈对微粒体血红素加氧酶和脾细胞色素P-450的影响
Arch Biochem Biophys. 1974 Jan;160(1):274-8. doi: 10.1016/s0003-9861(74)80034-2.
6
Purification and partial characterization of hepatic microsomal cytochrome P-450s from phenobarbital- and 3-methylcholanthrene-treated rats.从苯巴比妥和3-甲基胆蒽处理的大鼠肝脏微粒体中纯化细胞色素P-450并进行部分特性鉴定
J Biochem. 1979 Nov;86(5):1383-94. doi: 10.1093/oxfordjournals.jbchem.a132655.
7
Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats.
J Biol Chem. 1978 Nov 10;253(21):7931-9.
8
Effects of clophen A50, 3-methylcholanthrene, pregnenolone-16 alpha-carbonitrile, and phenobarbital on the hepatic microsomal cytochrome P-450-dependent monooxygenase system in rainbow trout, Salmo gairdneri, of different age and sex.氯芬A50、3-甲基胆蒽、孕烯醇酮-16α-腈和苯巴比妥对不同年龄和性别的虹鳟（Salmo gairdneri）肝脏微粒体细胞色素P-450依赖性单加氧酶系统的影响。
Toxicol Appl Pharmacol. 1980 Jul;54(3):420-30. doi: 10.1016/0041-008x(80)90169-6.
9
Effect of a catatoxic steroid pregnenolone-16alpha-carbonitrile, on rat liver microsomal subfractions.
Exp Mol Pathol. 1974 Dec;21(3):313-21. doi: 10.1016/0014-4800(74)90098-7.
10
3,4,5,3',4'-Pentachlorobiphenyl as a useful inducer for purification of rat liver microsomal cytochrome P448.
Biochem Biophys Res Commun. 1979 Dec 14;91(3):1140-7. doi: 10.1016/0006-291x(79)91999-5.

引用本文的文献

1
Recollection of the early years of the research on cytochrome P450.细胞色素 P450 研究早期的回忆。
Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(10):617-40. doi: 10.2183/pjab.87.617.
2
Purification and characterization of the hepatic CYP2C and 3A isozymes from phenobarbitone pretreated rhesus monkey.从苯巴比妥预处理的恒河猴中纯化和鉴定肝脏CYP2C和3A同工酶。
Mol Cell Biochem. 1999 Aug;198(1-2):79-88. doi: 10.1023/a:1006902212598.
3
Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif.
一种主要的糖皮质激素诱导型CYP3A基因的地塞米松反应性由与糖皮质激素受体结合基序无关的元件介导。
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4666-70. doi: 10.1073/pnas.93.10.4666.
4
Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase.人细胞色素P450 3A4：含NADPH-P450还原酶的纯化重组融合蛋白的酶学性质
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11748-52. doi: 10.1073/pnas.90.24.11748.
5
Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism.细胞色素P450 2D6和3A4在乙基吗啡代谢中作用的证据。
Br J Clin Pharmacol. 1995 Jan;39(1):77-80. doi: 10.1111/j.1365-2125.1995.tb04413.x.
6
Stimulation of de novo synthesis of cytochrome P-450 by phenobarbital in primary nonproliferating cultures of adult rat hepatocytes.苯巴比妥对成年大鼠肝细胞原代非增殖培养物中细胞色素P-450从头合成的刺激作用。
Proc Natl Acad Sci U S A. 1982 May;79(9):2922-6. doi: 10.1073/pnas.79.9.2922.
7
Measurement of the metabolism of cytochrome P-450 in cultured hepatocytes by a quantitative and specific immunochemical method.用定量特异性免疫化学方法测定培养肝细胞中细胞色素P-450的代谢
Biochem J. 1982 Apr 15;204(1):281-90. doi: 10.1042/bj2040281.
8
At least six forms of extremely homologous cytochromes P-450 in rat liver are encoded at two closely linked genetic loci.大鼠肝脏中至少六种形式的高度同源细胞色素P-450是由两个紧密连锁的基因位点编码的。
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6542-6. doi: 10.1073/pnas.80.21.6542.
9
Is cytochrome P-450 transported from the endoplasmic reticulum to the Golgi apparatus in rat hepatocytes?细胞色素P - 450在大鼠肝细胞中是从内质网转运到高尔基体的吗？
J Cell Biol. 1985 Nov;101(5 Pt 1):1733-40. doi: 10.1083/jcb.101.5.1733.
10
Identification of an inducible form of cytochrome P-450 in human liver.人肝脏中一种可诱导形式细胞色素P-450的鉴定。
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6310-4. doi: 10.1073/pnas.82.18.6310.