Bunch T W, O'Duffy J D
Mayo Clin Proc. 1980 Mar;55(3):161-79.
In patients with rheumatoid arthritis who do not respond to therapy with salicylates or nonsteroidal anti-inflammatory agents, stronger and potentially more toxic drugs are then considered. At the present time in the United States, this generally means a trial of hydroxychloroquine, gold, penicillamine, azathioprine, or cyclophosphamide. Each of these drugs is discussed with regard to pharmacology and possible modes of action, pertinent clinical studies, and toxicity.
对于那些对水杨酸盐或非甾体抗炎药治疗无反应的类风湿性关节炎患者，会考虑使用更强效且可能毒性更大的药物。目前在美国，这通常意味着试用羟氯喹、金制剂、青霉胺、硫唑嘌呤或环磷酰胺。将针对这些药物的药理学、可能的作用方式、相关临床研究及毒性进行讨论。
