一个免疫球蛋白重链基因由至少两个重组事件形成。
An immunoglobulin heavy-chain gene is formed by at least two recombinational events.
作者信息
Davis M M, Calame K, Early P W, Livant D L, Joho R, Weissman I L, Hood L
出版信息
Nature. 1980 Feb 21;283(5749):733-9. doi: 10.1038/283733a0.
The events of B-cell differentiation can be reconstructed in part through an analysis of the organisation of heavy-chain gene segments in differentiated B cells. A mouse immunoglobulin alpha heavy-chain gene is composed of at least three noncontiguous germ-line DNA segments--a VH gene segment, a JH gene segment associated with the Cmu gene segment, and the C alpha gene segment. These gene segments are joined together by two distinct types of DNA rearrangements--a V-J joining and a CH switch.
通过分析分化的B细胞中重链基因片段的组织方式，可部分重建B细胞分化的过程。小鼠免疫球蛋白α重链基因至少由三个不连续的种系DNA片段组成——一个VH基因片段、一个与Cμ基因片段相关的JH基因片段以及Cα基因片段。这些基因片段通过两种不同类型的DNA重排连接在一起——V-J连接和CH转换。
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