Stewart R M, Williams R S, Lukl P, Schoenen J
Acta Neuropathol. 1978 Jun 30;42(3):231-5. doi: 10.1007/BF00690362.
An infant with multiple congenital anomalies was found at autopsy to have a porencencephalic defect on the ventral surface of the left frontal lobe. The intracranial defect was seen in association with an anomalous configuration of the circle of Willis. The zone of tissue destruction corresponded to the vascular territory of the anterior choroidal and lenticulo-striate branches of the proximal middle cerebral arteries, which were absent on the left. The developmental anomaly of the circle of Willis may have predisposed to tissue destruction by compromising cerebral perfusion at midgestation, a stage of rapid brain growth.
一名患有多种先天性异常的婴儿在尸检时被发现左额叶腹侧有一个脑穿通畸形缺损。颅内缺损与 Willis 环的异常形态相关。组织破坏区域对应于大脑中动脉近端脉络膜前支和豆纹状支的血管供应区，左侧这些血管缺如。Willis 环的发育异常可能在妊娠中期（脑快速生长阶段）因损害脑灌注而导致组织破坏。
