Van Bijsterveld O P, Post H
Br J Ophthalmol. 1980 Jan;64(1):33-6. doi: 10.1136/bjo.64.1.33.
Trifluorothymidine (TFT) and adenine arabinoside (ara-A) are effective antiviral drugs with a very low toxicity for the cornea. In our study no difference between these 2 drugs in antiviral activity was noted. The average healing time for TFT was 11-14 days and for ara-A 10-54 days. These data differ markedly from those of other studies. This was the result of the use of additional criteria for healing of the lesion. Not only absence of fluorescein staining of the cornea but also the absence of oedema and cystic changes in the epithelium over the previous ulcer were considered criteria for healing. In addition to clearly defined healing criteria and the healing time we found the interval between the first symptoms and the commencement of the therapy of greatest importance in the clinical evaluation of antiviral drug efficacy. An effort was made to approximate this relationship for TFT and ara-A mathematically.
三氟胸腺嘧啶核苷（TFT）和阿糖腺苷（ara - A）是对角膜毒性极低的有效抗病毒药物。在我们的研究中，未发现这两种药物在抗病毒活性上有差异。TFT的平均愈合时间为11 - 14天，ara - A为10 - 54天。这些数据与其他研究的数据明显不同。这是使用了额外的病变愈合标准的结果。不仅角膜无荧光素染色，而且先前溃疡上方上皮无水肿和囊性改变也被视为愈合标准。除了明确界定的愈合标准和愈合时间外，我们发现在抗病毒药物疗效的临床评估中，首次出现症状与开始治疗之间的间隔最为重要。我们试图用数学方法来近似TFT和ara - A的这种关系。
