Kubota K, Tonoike M, Mikami A
Brain Res. 1980 Feb 3;183(1):29-42. doi: 10.1016/0006-8993(80)90117-1.
Ninety-nine single neuron activities of the dorsolateral prefrontal cortex of 3 monkeys were recorded during performance of a Konorski task. Green or red lights were presented successively with a separation of fixed delay interval. The monkey responded as soon as the second stimulus was presented. If the two stimuli were color-matched, the 'YES' lever press was rewarded; if the two stimuli were not, the 'NO' lever press was rewarded. In the second task, after paired color stimuli, a tone pip was presented as the 'GO' signal for lever presses. During sample and matching periods 50 neurons increased their discharge rates and 10 decreased. In 86% of increasing type neurons rate increase occurred during both periods. During auditory GO periods, 27 neurons increased their rates and 11 decreased. Discharge peak was before or at the moment of hold key release. In 60% of these neurons were also observed the rate changes to sample and matching stimuli. Differential activations between left and right levers were found in 20%. It was suggested that the prefrontal cortex is related to a sensorial attention mechanism to the visual stimulus which enables correct choice of the behavior to be rewarded.
在3只猴子执行科诺尔斯基任务期间，记录了其背外侧前额叶皮层的99个单神经元活动。绿色或红色灯光相继呈现，间隔固定延迟时间。猴子在第二个刺激出现时立即做出反应。如果两个刺激颜色匹配，按下“是”杠杆会得到奖励；如果不匹配，按下“否”杠杆会得到奖励。在第二个任务中，成对颜色刺激后，会出现一个短音作为杠杆按压的“开始”信号。在样本和匹配阶段，50个神经元放电率增加，10个神经元放电率降低。在86%的放电率增加型神经元中，两个阶段都出现了放电率增加。在听觉“开始”阶段，27个神经元放电率增加，11个神经元放电率降低。放电峰值出现在松开保持键之前或之时。在这些神经元中，60%在样本和匹配刺激时也观察到了放电率变化。20%的神经元发现左右杠杆之间存在差异激活。研究表明，前额叶皮层与对视觉刺激的感觉注意机制有关，该机制能使动物正确选择获得奖励的行为。
