Mehta R G, Moon R C
Cancer Res. 1980 Apr;40(4):1109-11.
The effect of retinoids on DNA synthesis was studied in the female Sprague-Dawley rat. Animals were treated with either solvent, 7,12-dimethylbenz(a)anthracene, or 1-methyl-1-nitro-sourea at 50 days of age and were placed on either placebo or retinyl acetate diet at 57 days of age. [3H]Thymidine incorporation into purified DNA isolated from mammary parenchymal cells was determined. Retinyl acetate effectively inhibited mammary cell DNA synthesis in both 1-methyl-1-nitrosourea- and 7,12-dimethylbenz(a)anthracene-treated animals; however, DNA synthesis in solvent-treated animals was unaffected.
在雌性斯普拉格-道利大鼠中研究了类视黄醇对DNA合成的影响。动物在50日龄时分别用溶剂、7,12-二甲基苯并(a)蒽或1-甲基-1-亚硝基脲处理，并在57日龄时分别给予安慰剂或醋酸视黄酯饮食。测定了从乳腺实质细胞分离的纯化DNA中[3H]胸苷的掺入情况。醋酸视黄酯有效地抑制了1-甲基-1-亚硝基脲和7,12-二甲基苯并(a)蒽处理动物的乳腺细胞DNA合成；然而，溶剂处理动物的DNA合成未受影响。
