[采用不同方法同种移植胰岛的大鼠中四氧嘧啶糖尿病病程的特点]

[Characteristics of the course of alloxan diabetes in rats with various methods of isografting the islands of Langerhans].

作者信息

Komissarenko V P, Turchin I S, Gordienko V M, Kravchenko V I, Matvienko G F

出版信息

Probl Endokrinol (Mosk). 1980 Jan-Feb;26(1):39-43.

Abstract

The course of alloxan diabetes in rats in different methods of isotransplantation of the islets of Langerhans isolated by means of trypsin, versen, and collagenase was studied. The transplanted islets can compensate insulin deficiency in rats with experimental diabetes. The period of normoglycemia depended on the number of the transplanted islets and the sites of their introduction. In intraperitoneal and intramuscular (m. rectus abdominis) methods of the islet tissue implantation normoglycemia was observed from 1.5 to 3.5 months, and in intrahepatic method it persisted from 4 to 10 months. The advantage of intrahepatic transplantation of the islets of Langerhans was shown.

摘要

研究了用胰蛋白酶、氨羧络合剂和胶原酶分离的胰岛在不同同种移植方法下对大鼠四氧嘧啶糖尿病病程的影响。移植的胰岛能够补偿实验性糖尿病大鼠的胰岛素缺乏。血糖正常期取决于移植胰岛的数量及其植入部位。在胰岛组织腹腔内和肌内（腹直肌）植入方法中，血糖正常状态持续1.5至3.5个月，而在肝内植入方法中，血糖正常状态持续4至10个月。结果显示了胰岛肝内移植的优势。