Vasilescu V, Katona E
Physiologie. 1980 Jan-Mar;17(1):3-17.
Data concerning the state and role of water (H2O) in the nerve, muscle and retina, obtained by the deuteriation technique, nuclear magnetic resonance (NMR) spectrometry and freeze-drying are reported. The existence of at least three distinct tissue water compartments is disclosed, whose sizes depend on the nature and state of the tissue. Some of these water populations appear to be indispensable to keeping up both the (supra) molecular architecture and the function of the system, while others have only a role in securing normal functioning. The mechanisms of the anesthetic action are also discussed and water involvement in this process is pointed out. Heavy water (D2O) effects on the cellular energy mechanisms are critically analysed. A change in the hydration degree of various species and the stabilization of the native conformation of biopolymers, as possible causes of heavy water effects, are remarked.
报道了通过氘化技术、核磁共振（NMR）光谱法和冷冻干燥获得的关于水（H₂O）在神经、肌肉和视网膜中的状态及作用的数据。揭示了至少存在三个不同的组织水隔室，其大小取决于组织的性质和状态。其中一些水群体似乎对于维持（超）分子结构和系统功能必不可少，而其他一些仅在确保正常功能方面起作用。还讨论了麻醉作用的机制，并指出了水在这一过程中的参与。对重水（D₂O）对细胞能量机制的影响进行了批判性分析。提到了各种物质水合程度的变化以及生物聚合物天然构象的稳定，作为重水效应的可能原因。
