Simon J, Zamora I, Martinez-sanchez F, Bartolome V
Acta Paediatr Scand. 1978 Jul;67(4):433-42. doi: 10.1111/j.1651-2227.1978.tb16350.x.
A modified technique of amnnitol-induced diuresis is described, in order to assess renal concentrating ability in infants and children. The infusion of 10% mannitol in 0.9% saline avoided the hypertonic saline overload and the fluid restriction period, both badly tolerated by infants and small children. In a control group of children aged from two months to seven years, the values of T(H2O) plotted against C(OSM) allowed to calculate the adjustment curve y=0.80x0.75, r=0.98 (p is less than 0.0001). In six patients with pituitary diabetes insipidus (PDI), the test was used in order to quantify the degree of ADH deficiency and evaluate the carbamazepine and clofibrate effect, in the renal concentrating mechanism. The test was tolerated perfectly in every case, obtaining qualitative and quantitative data and avoiding the hyponatremia and hypokalemia produced by the mannitol.
本文描述了一种改良的甘露醇诱导利尿技术，用于评估婴幼儿的肾脏浓缩能力。在0.9%盐水中输注10%甘露醇可避免高渗盐水过载和液体限制期，而婴幼儿对这两者的耐受性都很差。在一个年龄从两个月到七岁的儿童对照组中，根据渗透压（C(OSM)）绘制的自由水清除率（T(H2O)）值可计算出调整曲线y = 0.80x0.75，r = 0.98（p小于0.0001）。在六例垂体性尿崩症（PDI）患者中，该试验用于量化抗利尿激素（ADH）缺乏的程度，并评估卡马西平和氯贝丁酯在肾脏浓缩机制中的作用。该试验在每种情况下耐受性都很好，获得了定性和定量数据，并且避免了甘露醇引起的低钠血症和低钾血症。
