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长期使用曲安奈德治疗哮喘期间影响肾上腺皮质抑制的因素。

Factors influencing adrenocortical suppression during long-term triamcinolone acetonide therapy in asthma.

作者信息

Droszcz W, Lech B, Malunowicz E, Piotrowska B

出版信息

Ann Allergy. 1980 Mar;44(3):174-6.

PMID:6767423
Abstract

The causes for an abnormal five-hour tetracosactrin test in 14 out of 75 patients (18.5% of the entire group), treated continuously with triamcinolone acetonide long-term (mean 3.2 years) for asthma or related syndromes, were investigated. The average daily dosage, duration of treatment and age of the patients were analyzed. Statistical analysis indicated that the risk of adrenocortical suppression was increased by the patient's age and the average patients under the age of 50, receiving less than 1.2 mg triamcinolone acetonide daily, only rarely develop adrenocortical functional impairment.

摘要

对75例长期(平均3.2年)连续使用曲安奈德治疗哮喘或相关综合征的患者进行调查,其中14例(占整个组的18.5%)促肾上腺皮质激素(二十四肽促皮质素)五小时试验结果异常。分析了患者的平均每日剂量、治疗持续时间和年龄。统计分析表明,肾上腺皮质抑制的风险因患者年龄而增加,50岁以下且每日接受曲安奈德少于1.2毫克的患者很少发生肾上腺皮质功能损害。

相似文献

1
Factors influencing adrenocortical suppression during long-term triamcinolone acetonide therapy in asthma.长期使用曲安奈德治疗哮喘期间影响肾上腺皮质抑制的因素。
Ann Allergy. 1980 Mar;44(3):174-6.
2
Assessment of adrenocortical function in asthmatic patients on long-term triamcinolone acetonide treatment.长期接受曲安奈德治疗的哮喘患者肾上腺皮质功能评估。
Ann Allergy. 1979 Jan;42(1):41-3.
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[Analysis of the causes of adrenal cortex hypofunction during long-term treatment with triamcinolone acetonide].[曲安奈德长期治疗期间肾上腺皮质功能减退的原因分析]
Pneumonol Pol. 1979 Aug-Sep;47(7-8):531-5.
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Long-term triamcinolone acetonide aerosol treatment in adult patients with chronic bronchial asthma.
Ann Allergy. 1980 Mar;44(3):131-7.
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[Adrenal cortex function during long-term treatment with triamcinolone acetonide].[曲安奈德长期治疗期间的肾上腺皮质功能]
Pneumonol Pol. 1979 Aug-Sep;47(7-8):527-30.
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[Long-term therapy using depot-corticoids and the adrenal cortex system].[使用长效糖皮质激素和肾上腺皮质系统的长期治疗]
Med Welt. 1971 Nov 27;48(71):1930-2.
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[Efficacy of long-term beclomethasone dipropionate inhalation therapy in pediatric patients with asthma, and its effect on height growth and adrenocortical functions].[丙酸倍氯米松长期吸入治疗小儿哮喘的疗效及其对身高增长和肾上腺皮质功能的影响]
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Adrenocortical function and responsiveness to tetracosactrin infusions after intra-articular treatment with triamcinolone acetonide and hydrocortisone acetate.关节腔内注射曲安奈德和醋酸氢化可的松后肾上腺皮质功能及对二十四肽促皮质素输注的反应性。
Clin Rheumatol. 1982 Sep;1(3):176-84. doi: 10.1007/BF02042771.
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Preliminary experience with triamcinolone acetonide during pregnancy.妊娠期间使用曲安奈德的初步经验。
J Matern Fetal Med. 1996 Nov-Dec;5(6):310-3. doi: 10.1002/(SICI)1520-6661(199611/12)5:6<310::AID-MFM3>3.0.CO;2-S.

引用本文的文献

1
Comparison of oral prednisolone and intramuscular depot triamcinolone in patients with severe chronic asthma.重度慢性哮喘患者口服泼尼松龙与肌内注射曲安奈德长效注射剂的比较。
Thorax. 1985 Mar;40(3):207-8. doi: 10.1136/thx.40.3.207.
2
Intramuscular triamcinolone acetonide in chronic severe asthma.慢性重度哮喘中肌肉注射曲安奈德
Thorax. 1985 Nov;40(11):840-5. doi: 10.1136/thx.40.11.840.