Lee M, Eguchi Y, Arishima K, Chan K K
Biol Neonate. 1980;37(3-4):153-7. doi: 10.1159/000241267.
Fetuses of ad libitum fed and calorie-restricted rats were unilaterally adrenalectomized on day 19. By day 20 ad libitum fed fetuses exhibited compensatory adrenal hypertrophy, but calorie-restricted fetuses did not. As this may be due to the elevated corticosteroid levels of the calorie-restricted dams, unilateral adrenalectomy was performed on fetuses of control and restricted rats bilaterally adrenalectomized on day 15. Fetuses of restricted and control rats exhibited compensatory hypertrophy. One effect of calorie restriction may be to increase the amount of maternal corticosteroids acting on the fetus.
对自由采食和热量限制大鼠的胎儿在第19天进行单侧肾上腺切除术。到第20天，自由采食的胎儿出现了代偿性肾上腺肥大，而热量限制的胎儿则没有。由于这可能是由于热量限制母鼠的皮质类固醇水平升高所致，因此对在第15天进行双侧肾上腺切除术的对照和限制大鼠的胎儿进行了单侧肾上腺切除术。限制和对照大鼠的胎儿均出现了代偿性肥大。热量限制的一个作用可能是增加作用于胎儿的母体皮质类固醇的量。
