Myers T J, Tembrevilla-Zubiri C L, Klatsky A U, Rickles F R
Blood. 1980 May;55(5):748-51.
During a 3-yr period, a patient with hemophilia A experienced 5 episodes of acute hepatitis within 7-16 days following 5 separate infusions of factor VIII (FVIII) concentrates. Although the exact mechanism of the recurrent hepatitis remains unclear, these episodes most likely represented repeated allergic reactions to an antigenic protein derived from the FVIII concentrates. Although no evidence was found for a specific humoral immune response to FVIII in the circulation of the patient, an isolated cellular immune response was suggested by the finding of in vitro lymphocyte stimulation in response to the FVIII concentrate. This unusual type of posttransfusion hepatitis must be added to the list of adverse responses to FVIII concentrates.
在3年期间，一名甲型血友病患者在5次分别输注凝血因子VIII（FVIII）浓缩物后的7至16天内经历了5次急性肝炎发作。尽管复发性肝炎的确切机制尚不清楚，但这些发作很可能代表了对FVIII浓缩物中衍生的抗原性蛋白质的反复过敏反应。尽管在患者的循环中未发现针对FVIII的特异性体液免疫反应的证据，但体外淋巴细胞对FVIII浓缩物刺激的反应提示存在孤立的细胞免疫反应。这种不寻常的输血后肝炎类型必须添加到FVIII浓缩物不良反应列表中。
