骨髓瘤骨髓酸性磷酸酶染色：38例患者的相关性研究

Myeloma bone marrow acid phosphatase staining: a correlative study of 38 patients.

作者信息

Bataille R, Durie B G, Sany J, Salmon S E

出版信息

Blood. 1980 May;55(5):802-5.

Abstract

Acid phosphatase (AP) activity of plasma cells was studied in 38 patients with multiple myeloma (MM). The average activity per cell was strong (mean score = 2.42; maximum score = 4) and the percentage of positive cells was greater than 90% in over 71% of patients. The average AP activity per cell was higher prior to treatment (3.06 +/- 0.53) compared to relapse (2.48 +/- 0.77) and remission (1.81 +/- 1.02 (p less than 0.05 and p less than 0.01, respectively). In correlation of AP activity with clinical features at the time of the study, the only significant difference was between kappa and lambda subtype. Patients with lambda MM had a higher average AP activity per cell in remission (2.71 +/- 0.43) as opposed to kappa MM (1.17 +/- 1.06, p less than 0.05 for difference). AP activity was not significantly correlated with degree of bone involvement. However, activity seemed to be a good marker of disease activity.

摘要

对38例多发性骨髓瘤（MM）患者的浆细胞酸性磷酸酶（AP）活性进行了研究。每个细胞的平均活性较强（平均评分=2.42；最高评分=4），超过71%的患者阳性细胞百分比大于90%。与复发（2.48±0.77）和缓解期（1.81±1.02）相比，治疗前每个细胞的平均AP活性更高（3.06±0.53）（分别为p<0.05和p<0.01）。在研究时，AP活性与临床特征的相关性方面，唯一显著差异在于κ和λ亚型之间。λ型MM患者缓解期每个细胞的平均AP活性较高（2.71±0.43），而κ型MM患者为（1.17±1.06，差异p<0.05）。AP活性与骨受累程度无显著相关性。然而，活性似乎是疾病活动的一个良好标志物。