Plant T M
Endocrinology. 1980 May;106(5):1451-4. doi: 10.1210/endo-106-5-1451.
Plasma concentrations of LH and FSH in immature male rhesus monkeys were determined at weekly intervals from birth until 300 days of age, and the effect of bilateral orchidectomy at 1 week of age on the neonatal pattern of gonadotropin secretion was studied. Plasma FSH and LH concentrations in intact animals were elevated during the first few months of neonatal life but then declined to undetectable values characteristic of the prepubertal state in this species. Neonatal castration, but not sham castration, resulted in a progressive and dramatic rise in circulating gonadotropin concentrations, which plateaued approximately 3 weeks later at values an order of magnitude greater than those observed in intact animals. The hypersecretion of LH and FSH after removal of the gonads was not sustained, however, and by 32 weeks of age plasma gonadotropin concentrations in the agonadal animals were indistinguishable from those in age-matched intact controls. These findings suggest that, in the rhesus monkey, the testes do not play a major role in determining the pattern of gonadotropin secretion throughout neonatal and prepubertal development. They further suggest that a profound inhibitory influence of nongonadal origin impinges upon the neuroendocrine control system governing gonadotropin secretion in the neonate, thereby initiating the diminished secretion of LH and FSH which is characteristic of the prepubertal stage of development in primates.
从出生到300日龄，每周测定未成熟雄性恒河猴血浆中促黄体生成素（LH）和促卵泡生成素（FSH）的浓度，并研究1周龄时双侧睾丸切除对新生儿促性腺激素分泌模式的影响。完整动物的血浆FSH和LH浓度在新生儿期的最初几个月升高，但随后下降至该物种青春期前状态特有的无法检测到的值。新生儿阉割而非假阉割导致循环促性腺激素浓度逐渐显著升高，大约3周后达到稳定水平，其值比完整动物中观察到的值高一个数量级。然而，去除性腺后LH和FSH的分泌亢进并未持续，到32周龄时，性腺切除动物的血浆促性腺激素浓度与年龄匹配的完整对照动物的浓度没有区别。这些发现表明，在恒河猴中，睾丸在整个新生儿期和青春期前发育过程中对促性腺激素分泌模式的决定作用不大。它们进一步表明，非性腺来源的深刻抑制性影响作用于控制新生儿促性腺激素分泌的神经内分泌控制系统，从而引发LH和FSH分泌减少，这是灵长类动物青春期前发育阶段的特征。
