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急性母体缺氧对绵羊胎儿氧合及脐循环的影响。

The effect of acute maternal hypoxia on fetal oxygenation and the umbilical circulation in the sheep.

作者信息

Parer J T

出版信息

Eur J Obstet Gynecol Reprod Biol. 1980 Feb;10(2):125-36. doi: 10.1016/0028-2243(80)90090-8.

DOI:10.1016/0028-2243(80)90090-8
PMID:6767635
Abstract

The mean oxygen consumption was 8.4 +/- 1.9 ml/min/kg in the near-term fetal sheep. In response to acute maternal hypoxia fetal O2 consumption decreased to lower than 50% of the control values. The decrease was rapidly instituted, proportional to the degree of hypoxia, sustained for up to 47 min and stable over this period. With increasing duration of hypoxia, a progressive metabolic acidosis developed. Recovery of oxygen consumption occurred rapidly after hypoxia ceased, though the acidosis was not resolved until 2 h later. Umbilical blood flow was maintained during maternal hypoxia and umbilical arterial and venous pressures increased. A fetal bradycardia invariably accompanied the hypoxia.

摘要

近足月胎羊的平均耗氧量为8.4±1.9毫升/分钟/千克。对急性母体缺氧的反应是,胎儿的氧气消耗量降至低于对照值的50%。这种下降迅速发生,与缺氧程度成正比,持续长达47分钟且在此期间保持稳定。随着缺氧持续时间的增加,逐渐出现代谢性酸中毒。缺氧停止后,氧气消耗迅速恢复,不过酸中毒直到2小时后才得到缓解。母体缺氧期间,脐血流量得以维持,脐动脉和静脉压力升高。缺氧总是伴随着胎儿心动过缓。

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