Lennerstrand G, Hanson J
Acta Physiol Scand. 1978 Jun;103(2):132-43. doi: 10.1111/j.1748-1716.1978.tb06200.x.
The postnatal development of the inferior oblique muscle in the cat has been studied with physiological and histochemical techniques. This paper describes the changes with age in isometric twitch and tetanic response characteristics. The twitch amplitude increased and the twitch contraction time (ct) and half-relaxation time (hrt) decreased almost linearly from birth to adulthood. The relation between the strength of nerve stimulation and twitch ct and hrt changed during development with a threshold slow response appearing at 10 weeks. Twitch responses in cats 6 weeks of age or older were of longer duration than in younger cats, in spite of the longer ct and hrt in young cats. Fusion frequency of the tetanic response reached a constant level in muscles 6 weeks or older. The maximum rate of tension rise remained the same from birth to 6 weeks of age and later increased markedly up to 20 weeks of age. The contracture induced by succinylcholine was the same in muscles of all ages. These data were related to previous findings on the postnatal development of fast and slow muscles and motor units in the hindlimb of the cat. A differentiation of the development of fast and slow eye muscle fibers is suggested. Slow fibres seemed to have completed their maturation at about ten weeks of age, while the development of fast fibre properties continued, probably up to the adult stage.
利用生理学和组织化学技术对猫的下斜肌产后发育进行了研究。本文描述了等长收缩抽搐和强直反应特征随年龄的变化。从出生到成年，抽搐幅度增加，抽搐收缩时间（ct）和半松弛时间（hrt）几乎呈线性下降。在发育过程中，神经刺激强度与抽搐ct和hrt之间的关系发生了变化，在10周时出现了阈值缓慢反应。尽管幼猫的ct和hrt较长，但6周龄及以上猫的抽搐反应持续时间比幼猫更长。6周龄及以上肌肉的强直反应融合频率达到恒定水平。从出生到6周龄，张力上升的最大速率保持不变，之后在20周龄时显著增加。琥珀酰胆碱诱导的挛缩在所有年龄段的肌肉中都是相同的。这些数据与之前关于猫后肢快肌和慢肌以及运动单位产后发育的研究结果相关。提示快、慢眼肌纤维的发育存在差异。慢纤维似乎在大约10周龄时完成了成熟，而快纤维特性的发育可能持续到成年阶段。
