Mashimo P A, Umemoto T, Slots J, Genco R J, Ellison S A
J Periodontol. 1980 Apr;51(4):190-2. doi: 10.1902/jop.1980.51.4.190.
POTENTIAL INFECTIVITY of subgingival plaque of Macaca arctoides in guinea pig leg muscle was examined before, during, and after chlorhexidine treatment. The regime of chlorhexidine administration did not appear to alter the monkey subgingival microflora markedly and had no demonstrable effects on the pathogenicity of the subgingival plaque. These data confirm previous suggestions that chlorhexidine essentially does not penetrate into the deeper part of periodontal pockets following a supragingival mode of administration.
