Brady K T, Balster R L, Meltzer L T, Schwertz D
Pharmacol Biochem Behav. 1980 Jan;12(1):67-71. doi: 10.1016/0091-3057(80)90417-7.
The effects of four arylcyclohexylamines on operant performance in rhesus monkeys were compared. Four rhesus monkeys were trained to lever press on a multiple fixed-interval 5 min time out 1 min schedule of food presentation during daily 1 1/2 hour sessions. Dose-response curves and median effective doses were determined for phencyclidine, N-ethyl-1-phenylcyclohexylamine, 1-(1-(2-thienyl) cyclohexyl) piperidine and ketamine. Ketamine was found to be approximately 1/10 as potent as the other drugs which were approximately equipotent. The drugs had qualitatively similar effects. High doses of all four drugs decreased overall response rates and the slopes of the dose-response curves were comparable. A dose-related rate-dependent effect was found for all four drugs. Onset and duration of the drug effects were also presented.
比较了四种芳基环己胺对恒河猴操作性行为的影响。四只恒河猴在每天1.5小时的实验时段内，按照多固定间隔5分钟、超时1分钟的食物呈现时间表接受杠杆按压训练。测定了苯环己哌啶、N-乙基-1-苯基环己胺、1-(1-(2-噻吩基)环己基)哌啶和氯胺酮的剂量反应曲线和半数有效剂量。结果发现，氯胺酮的效力约为其他几种效力相当的药物的1/10。这些药物具有定性相似的效应。所有四种药物的高剂量均降低了总体反应率，且剂量反应曲线的斜率相当。发现所有四种药物都有与剂量相关的速率依赖性效应。还呈现了药物效应的起效时间和持续时间。
