Fuchs V, Coper H
Psychopharmacology (Berl). 1980 Feb;67(2):181-8. doi: 10.1007/BF00431975.
After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected. The concentration of 5-hydroxytryptamine (5-HT) is not influenced by 6-OHDA or 6-OHDA + DMI. Chronic morphine treatment to some extent enhances reduced NA and DA levels after 6-OHDA, but the decreased central catecholamine (CA) content after 6-OHDA + DMI is not raised. Morphine analgesia is highly attenuated in 6-OHDA and 6-OHDA + DMI mice. The reduction occurs in non-tolerant as well as in tolerant animals. The acute effect of morphine on body temperature is abolished with 6-OHDA, but not with 6-OHDA + DMI, whereas the interaction of central CA in morphine-induced running shows distinctly marked reduction with 6-OHDA + DMI, but not with 6-OHDA. Acute toxicity is enhanced by 6-OHDA + DMI whereas the development of tolerance against the toxicity of morphine is diminished by 6-OHDA. Lack of CA in the brain decreases sensitivity against naloxone withdrawal in acute as well as in chronic experiments.
给小鼠脑池内注射6-羟基多巴胺（6-OHDA）后，脑内去甲肾上腺素（NA）和多巴胺（DA）减少，不过NA的减少更为明显。在经去甲丙咪嗪（DMI）预处理的动物脑池内注射6-OHDA会增强DA的耗竭，而NA受到部分保护。5-羟色胺（5-HT）的浓度不受6-OHDA或6-OHDA + DMI的影响。慢性吗啡处理在一定程度上可提高6-OHDA处理后降低的NA和DA水平，但6-OHDA + DMI处理后降低的中枢儿茶酚胺（CA）含量并未升高。吗啡镇痛在6-OHDA和6-OHDA + DMI小鼠中显著减弱。这种减弱在未耐受以及耐受的动物中均会出现。6-OHDA可消除吗啡对体温的急性作用，但6-OHDA + DMI不会，而在吗啡诱导的奔跑中，中枢CA的相互作用在6-OHDA + DMI处理时明显显著降低，但6-OHDA处理时不会。6-OHDA + DMI会增强急性毒性，而6-OHDA会减弱对吗啡毒性的耐受性发展。脑内缺乏CA会降低急性和慢性实验中对纳洛酮戒断的敏感性。
