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膳食乙氧喹对大鼠肝脏UDP-葡萄糖醛酸基转移酶的诱导作用。

Induction of rat hepatic UDP-glucuronosyltransferases by dietary ethoxyquin.

作者信息

Bock K W, Kahl R, Lilienblum W

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1980 Jan;310(3):249-52. doi: 10.1007/BF00499919.

DOI:10.1007/BF00499919
PMID:6769055
Abstract

Dietary administration of 0.5% ethoxyquin markedly enhanced rat hepatic UDP-glucuronosyltransferase activities. Both 3-methylcholanthrene- and phenobarbital-inducible glucuronidation reactions were stimulated by the antioxidant. In contrast, phenobarbital-inducible bilirubin glucuronidation was not affected by ethoxyquin.

摘要

给予0.5%乙氧喹啉的饮食显著增强了大鼠肝脏UDP-葡萄糖醛酸基转移酶的活性。抗氧化剂刺激了3-甲基胆蒽和苯巴比妥诱导的葡萄糖醛酸化反应。相比之下，苯巴比妥诱导的胆红素葡萄糖醛酸化不受乙氧喹啉的影响。

相似文献

1
Induction of rat hepatic UDP-glucuronosyltransferases by dietary ethoxyquin.膳食乙氧喹对大鼠肝脏UDP-葡萄糖醛酸基转移酶的诱导作用。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Jan;310(3):249-52. doi: 10.1007/BF00499919.
2
Intralobular distribution of UDP-glucuronosyltransferase in livers from untreated, 3-methylcholanthrene- and phenobarbital-treated rats.
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3
Differential induction of rat liver microsomal UDP-glucuronosyltransferase activites by various inducing agents.多种诱导剂对大鼠肝脏微粒体UDP-葡萄糖醛酸基转移酶活性的差异诱导作用。
Biochem Pharmacol. 1982 Mar 15;31(6):907-13. doi: 10.1016/0006-2952(82)90319-7.
4
Differential induction of glutathione S-transferase subunits by phenobarbital, 3-methylcholanthrene and ethoxyquin in rat liver and kidney.苯巴比妥、3-甲基胆蒽和乙氧喹对大鼠肝脏和肾脏中谷胱甘肽S-转移酶亚基的差异诱导作用。
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Ethoxyquin as an inducer and inhibitor of phenobarbital-type cytochrome P-450 in rat liver microsomes.乙氧喹作为大鼠肝微粒体中苯巴比妥型细胞色素P - 450的诱导剂和抑制剂。
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Glucuronide formation of various drugs in liver microsomes and in isolated hepatocytes from phenobarbital- and 3-methylcholanthrene-treated rats.
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Characterization of 1-hydroxypyrene as a novel marker substrate of 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase(s).1-羟基芘作为3-甲基胆蒽诱导型苯酚UDP-葡萄糖醛酸基转移酶的新型标记底物的表征。
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Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers.
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Male rat hepatic UDP-glucuronosyltransferase activity toward thyroxine. Activation and induction properties--relation with thyroxine plasma disappearance rate.雄性大鼠肝脏对甲状腺素的UDP-葡萄糖醛酸基转移酶活性。激活和诱导特性——与甲状腺素血浆消失率的关系
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Comp Biochem Physiol B. 1987;87(3):513-22. doi: 10.1016/0305-0491(87)90046-0.

引用本文的文献

1
An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.一种来自大鼠肝脏的乙氧喹诱导型醛还原酶可代谢黄曲霉毒素B1，它定义了醛酮还原酶的一个亚家族。
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10350-4. doi: 10.1073/pnas.90.21.10350.

本文引用的文献

1
Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin.酚类抗氧化剂和乙氧喹对多环烃致癌和毒性作用的抑制
J Natl Cancer Inst. 1972 May;48(5):1425-30.
2
Reversibility of hepatic changes caused by ethoxyquin.乙氧喹所致肝脏变化的可逆性
Biochem Pharmacol. 1974 Jul 1;23(13):1871-6. doi: 10.1016/0006-2952(74)90196-8.
3
Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase.苯巴比妥和3-甲基胆蒽对大鼠肝微粒体UDP-葡萄糖醛酸基转移酶底物特异性的影响。
Biochim Biophys Acta. 1973 Nov 15;327(1):46-56. doi: 10.1016/0005-2744(73)90102-2.
4
Ethoxyquin as an inducer and inhibitor of phenobarbital-type cytochrome P-450 in rat liver microsomes.乙氧喹作为大鼠肝微粒体中苯巴比妥型细胞色素P - 450的诱导剂和抑制剂。
Toxicol Appl Pharmacol. 1977 Jun;40(3):473-83. doi: 10.1016/0041-008x(77)90074-6.
5
Commentary: Control of UDP-glucuronyltransferase activity.
Biochem Pharmacol. 1975 Oct 15;24(20):1835-41. doi: 10.1016/0006-2952(75)90399-8.
6
Ethoxyquin feeding to rats increases liver microsome-catalyzed formation of benzo(a)pyrene diol epoxide--DNA adduct.给大鼠喂食乙氧喹会增加肝微粒体催化的苯并(a)芘二醇环氧化物与DNA加合物的形成。
Biochem Biophys Res Commun. 1978 Dec 14;85(3):938-45. doi: 10.1016/0006-291x(78)90634-4.
7
Effects of 2(3)-tert-butyl-4-hydroxyanisole administration on the activities of several hepatic microsomal and cytoplasmic enzymes in mice.给予2(3)-叔丁基-4-羟基茴香醚对小鼠几种肝微粒体和细胞质酶活性的影响。
Biochem Pharmacol. 1979 Jun 15;28(12):1917-21. doi: 10.1016/0006-2952(79)90645-2.
8
Induction of rat hepatic epoxide hydratase by dietary antioxidants.膳食抗氧化剂对大鼠肝脏环氧化物水解酶的诱导作用。
Toxicol Appl Pharmacol. 1979 Feb;47(2):217-27. doi: 10.1016/0041-008x(79)90315-6.
9
Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.膳食抗氧化剂对肝脏谷胱甘肽S-转移酶活性的提升及对苯并(a)芘诱变代谢产物的防护作用
Cancer Res. 1978 Dec;38(12):4486-95.
10
Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital.大鼠肝脏微粒体UDP-葡萄糖醛酸基转移酶的纯化。两种可被3-甲基胆蒽或苯巴比妥诱导的酶形式的分离。
Eur J Biochem. 1979 Jul;98(1):19-26. doi: 10.1111/j.1432-1033.1979.tb13155.x.