A comparative study of the prophylactic effect of ketotifen and sodium cromoglycate in children with pollen-induced asthma.

Thirty-six children with verified deciduous tree pollen-induced asthma were studied with respect to the prophylactic effect and tolerance of ketotifen, in comparison to disodium cromoglycate. Double-blind technique was used and the study was performed during the deciduous tree pollen season. Daily pollen counts were performed, and allergic symptoms, additional medication and pulmonary expiratory flow were recorded. Both drugs showed a good prophylactic effect on the asthma symptoms. No significant differences were found between the two substances tested and no adverse reactions or side effects were noted.