Bleiber R, Eggert W, Reichmann G, Kunze D
Acta Haematol. 1980;63(3):117-23. doi: 10.1159/000207381.
Lipids in erythrocytes and plasma of children and adults with terminal renal insufficiency were determined and compared with those of normal controls. The erythrocyte phospholipids in uremic patients were altered in phosphatidylethanolamine (absolutely and relatively elevated) and in lecithin (relatively diminished). Sphingomyelin, phosphatidylserine, total erythrocyte phospholipid content and cholesterol were within the normal range. The detailed analysis of the distribution of plasma phospholipids showed an increase in all phospholipids except phosphatidylserine. The unesterified plasma cholesterol was also found to be elevated. The fatty acid distribution in the individual erythrocyte phospholipids showed the following variations in comparison with controls: one main fatty acid was significantly decreased in sphingomyelin and in lecithin and slightly decreased in phosphatidylethanolamine. It could be shown that the lipid alterations in uremic erythrocytes were quite different from those in plasma. There were not typical signs for an increased lipid peroxidation in the erythrocytes of patients with renal insufficiency.
对患有终末期肾功能不全的儿童和成人的红细胞及血浆中的脂质进行了测定，并与正常对照组进行了比较。尿毒症患者的红细胞磷脂中，磷脂酰乙醇胺（绝对含量和相对含量均升高）和卵磷脂（相对减少）发生了改变。鞘磷脂、磷脂酰丝氨酸、红细胞磷脂总含量和胆固醇均在正常范围内。对血浆磷脂分布的详细分析表明，除磷脂酰丝氨酸外，所有磷脂均增加。未酯化的血浆胆固醇也升高。与对照组相比，单个红细胞磷脂中的脂肪酸分布有以下变化：鞘磷脂和卵磷脂中的一种主要脂肪酸显著减少，磷脂酰乙醇胺中的该脂肪酸略有减少。结果表明，尿毒症红细胞中的脂质改变与血浆中的脂质改变有很大不同。肾功能不全患者的红细胞中没有脂质过氧化增加的典型迹象。
