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用野百合碱处理的大鼠肺动脉中胶原蛋白合成增加。

Increase of collagen synthesis in pulmonary arteries of monocrotaline-treated rats.

作者信息

Kameji R, Otsuka H, Hayashi Y

出版信息

Experientia. 1980 Apr 15;36(4):441-2. doi: 10.1007/BF01975136.

DOI:10.1007/BF01975136
PMID:6769696
Abstract

Collagen synthesis in the pulmonary artery in animals with pulmonary hypertension was studied using monocrotaline-treated rats as a model. Incorporation of 14C-lateled proline into collagenase-digestible protein in the pulmonary artery was found to be 4-5 times higher in monocrotaline-treated rats than in control rats.

摘要

以用野百合碱处理的大鼠为模型，研究了肺动脉高压动物的肺动脉胶原合成情况。发现用野百合碱处理的大鼠肺动脉中，14C标记的脯氨酸掺入胶原酶可消化蛋白的量比对照大鼠高4至5倍。

相似文献

1
Increase of collagen synthesis in pulmonary arteries of monocrotaline-treated rats.用野百合碱处理的大鼠肺动脉中胶原蛋白合成增加。
Experientia. 1980 Apr 15;36(4):441-2. doi: 10.1007/BF01975136.
2
Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline. A biochemical and ultrastructural study.与野百合碱诱导的进行性肺动脉高压相关的弹性蛋白和胶原蛋白合成改变。一项生化和超微结构研究。
Lab Invest. 1988 Feb;58(2):184-95.
3
Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-treated rats.用野百合碱处理的大鼠肺血管中进行性炎症和结构变化。
Microvasc Res. 1989 Jul;38(1):57-80. doi: 10.1016/0026-2862(89)90017-4.
4
Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension.内皮素和5-羟色胺对肺动脉高压大鼠肺动脉的作用
Eur J Pharmacol. 1990 Feb 6;176(2):159-68. doi: 10.1016/0014-2999(90)90524-a.
5
Na+/K(+)-adenosine triphosphatase activity of pulmonary arteries after intoxication with the pyrrolizidine alkaloid, monocrotaline.
J Pharmacol Exp Ther. 1990 Jan;252(1):70-6.
6
The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells.
Am J Pathol. 1991 Mar;138(3):707-19.
7
Potassium dependent relaxation of isolated pulmonary artery segments following ingestion of monocrotaline.
Proc West Pharmacol Soc. 1988;31:313-5.
8
Pulmonary vasculature in monocrotaline-induced hypertensive rats on magnesium therapy.接受镁治疗的野百合碱诱导高血压大鼠的肺血管系统
Microcirc Endothelium Lymphatics. 1990 Aug-Oct;6(4-5):267-83.
9
Altered artery mechanics and structure in monocrotaline pulmonary hypertension.单氰胺所致肺动脉高压中动脉力学和结构的改变
J Appl Physiol (1985). 1988 Nov;65(5):2326-31. doi: 10.1152/jappl.1988.65.5.2326.
10
[Experimental glomerulopathy induced by monocrotaline in rats].
Nihon Jinzo Gakkai Shi. 1986 Feb;28(2):109-14.

引用本文的文献

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Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension.肺血流动力学改变大鼠肺动脉对损伤的反应。肺动脉高压的新生内膜模型。
Am J Pathol. 1997 Oct;151(4):1019-25.
2
The role of vascular injury and hemodynamics in rat pulmonary artery remodeling.血管损伤和血流动力学在大鼠肺动脉重塑中的作用。
J Clin Invest. 1996 Jul 15;98(2):434-42. doi: 10.1172/JCI118809.
3
Crotalaria-induced pulmonary hypertension. Uptake of 3H-thymidine by the cells of the pulmonary circulation and alveolar walls.

本文引用的文献

1
INFLUENCE OF RAT STRAIN ON PULMONARY VASCULAR RESPONSES TO MONOCROTALINE FEEDING.大鼠品系对肺动脉对野百合碱喂养反应的影响
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Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds.大鼠因摄入美丽猪屎豆种子而产生的肺动脉高压。
Thorax. 1967 Mar;22(2):176-9. doi: 10.1136/thx.22.2.176.
猪屎豆属植物诱发的肺动脉高压。肺循环和肺泡壁细胞对³H-胸腺嘧啶核苷的摄取。
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4
PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model.血小板活化因子受体阻断可抑制大鼠野百合碱模型中的肺血管变化。
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5
Monocrotaline-induced structural remodeling of the intra-acinar pulmonary arteries and pulmonary hypertension.野百合碱诱导的腺泡内肺动脉结构重塑与肺动脉高压。
J Tongji Med Univ. 1992;12(4):227-33. doi: 10.1007/BF02887855.
4
Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents.高血压大鼠血管中胶原蛋白合成增加及其被抗高血压药物逆转。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3019-23. doi: 10.1073/pnas.71.8.3019.
5
Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins.在存在其他蛋白质的情况下，使用不含蛋白酶的胶原酶混合物对放射性胶原蛋白进行特异性测定。
Biochemistry. 1971 Mar 16;10(6):988-94. doi: 10.1021/bi00782a009.
6
Cor pulmonale in rats.大鼠肺心病
Lab Invest. 1967 Jun;16(6):875-81.
7
Hypertension: increase of collagen biosynthesis in arteries but not in veins.高血压：动脉中胶原蛋白生物合成增加，而静脉中则不然。
Science. 1977 Oct 28;198(4315):403-5. doi: 10.1126/science.198877.
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Collagen biosynthesis in blood vessels of brain and other tissues of the hypertensive rat.
Science. 1975 Nov 28;190(4217):898-900. doi: 10.1126/science.171771.