高血压大鼠血管中胶原蛋白合成增加及其被抗高血压药物逆转。
Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents.
作者信息
Ooshima A, Fuller G C, Cardinale G J, Spector S, Udenfriend S
出版信息
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3019-23. doi: 10.1073/pnas.71.8.3019.
Abstract
Collagen synthesis is increased in the aortas, mesenteric arteries, and to a lesser extent, in the hearts of rats either made hypertensive with desoxycorticosterone acetate-salt or that are spontaneously hypertensive. Several markers of collagen biosynthesis were shown to be increased, including prolyl hydroxylase (EC 1.14.11.2; proline, 2-oxoglutarate dioxygenase), prolyl hydroxylase-related antigen, total collagen content, and the incorporation of [(3)H]proline into total protein and into collagen. The antihypertensive agents chlorothiazide and reserpine, when administered before the onset of hypertension in the rats treated with desoxycorticosterone acetate-salt, prevented or diminished the increase in collagen biosynthesis. When reserpine was given after the onset of hypertension, prolyl hydroxylase activity was decreased concomitant with the decrease in blood pressure. Treatment with reserpine is particularly effective in diminishing arterial prolyl hydroxylase activity.
摘要
在通过醋酸脱氧皮质酮-盐诱导高血压的大鼠或自发性高血压大鼠中，主动脉、肠系膜动脉以及程度较轻的心脏中的胶原蛋白合成增加。胶原蛋白生物合成的几种标志物显示增加，包括脯氨酰羟化酶（EC 1.14.11.2；脯氨酸，2-氧代戊二酸双加氧酶）、脯氨酰羟化酶相关抗原、总胶原蛋白含量以及[³H]脯氨酸掺入总蛋白和胶原蛋白中的量。在醋酸脱氧皮质酮-盐处理的大鼠高血压发作前给予降压药氯噻嗪和利血平，可预防或减少胶原蛋白生物合成的增加。当在高血压发作后给予利血平时，脯氨酰羟化酶活性随着血压下降而降低。利血平治疗在降低动脉脯氨酰羟化酶活性方面特别有效。
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