Schenker J G, Laufer N, Weinstein D, Yarkoni S
Eur J Obstet Gynecol Reprod Biol. 1980 May;10(4):257-68. doi: 10.1016/0028-2243(80)90006-4.
Five quintuplet pregnancies, following induction of ovulation with clomiphene and HMG-HCG, are the subject of this communication. In 3 women, pregnancy was associated with ovarian overstimulation, and two patients required emergency surgery because of torsion of an ovarian cyst. Two women aborted in mid-trimester, while the other 3 delivered by cesarean section at 33-35 wk gestation. 15 babies were born, weighing 700-2200 g. 8 infants suffered from respiratory distress syndrome and 5 babies were born with correctable malformations. 13 newborns survived, and all are mentally and physically well-developed. Four of the 5 women conceived again. The management of the patients during multiple gestation and the outcome of pregnancy are discussed.
本文报道了5例经克罗米芬及人绝经期促性腺激素-人绒毛膜促性腺激素诱导排卵后发生的五胎妊娠。3例患者妊娠合并卵巢过度刺激综合征,2例因卵巢囊肿扭转而行急诊手术。2例患者在孕中期流产,另外3例在妊娠33 - 35周时行剖宫产分娩。共娩出15名婴儿,体重700 - 2200克。8名婴儿患有呼吸窘迫综合征,5名婴儿出生时伴有可纠正的畸形。13名新生儿存活,且身心发育良好。5例患者中有4例再次受孕。文中讨论了多胎妊娠患者的管理及妊娠结局。