Lamont J A
Acta Genet Med Gemellol (Roma). 1982;31(3-4):247-53. doi: 10.1017/s0001566000008369.
A literature review of the occurrence of multiple pregnancies associated with artificial induction of ovulation is reported. This report considers three treatment schedules: (1) clomiphene citrate; (2) human pituitary gonadotrophin with human chorionic gonadotrophin; and (3) human menopausal gonadotrophin with human chorionic gonadotrophin. The majority of the increase in twinning is related to hyperstimulation of the ovary by these medications, resulting in dizygotic twinning. The true incidence of twin pregnancy cannot be calculated because the vital statistics of all nations report live birth rates. Increased rates of fetal wastage, late abortion and prematurity associated with the occurrence of multiple pregnancies are overlooked by these statistics. The increased incidence of twinning appears to be related to the type and dosage of medication used, and the patient's underlying problem.
本文报道了一篇关于与人工诱导排卵相关的多胎妊娠发生率的文献综述。本报告考虑了三种治疗方案：（1）枸橼酸氯米芬；（2）人垂体促性腺激素与人绒毛膜促性腺激素；（3）人绝经期促性腺激素与人绒毛膜促性腺激素。双胎妊娠增加的主要原因是这些药物对卵巢的过度刺激，导致双卵双胎。由于所有国家的人口统计数据均报告活产率，因此无法计算双胎妊娠的真实发生率。这些统计数据忽略了与多胎妊娠发生相关的胎儿流产、晚期流产和早产率的增加。双胎妊娠发生率的增加似乎与所用药物的类型和剂量以及患者的潜在问题有关。
