兔免疫球蛋白的同种异型：a位点的第五个等位基因。

Allotypy of rabbit immunoglobulins: a fifth allele at the a locus.

作者信息

Brézin C, Cazenave P A

出版信息

J Immunol. 1980 Jul;125(1):59-62.

Abstract

Studies in wild rabbits (Oryctolagus cuniculus) allowed the detection of a fifth allele (a101) at the a locus of rabbit immunoglobulins. The structures responsible for the A101 allotypic specificity have been found on both IgG and IgM. Their location is on the Fab fragment, on the H chain. None of the rabbits possessing A101 allotypic specificity possessed two known allotypic specificities of the a series. Genetic evidence by breeding studies agree with assignment of A101 to the a series and allow to designate this allotypic specificity as a101. a101 has been found in wild rabbits in different areas in France. It has no detectable cross-reactivity with the known allotypes. The genetic polymorphism of immunoglobulins is much larger in the Oryctolagus cuniculus species than the one described in the domestic form of the species.

摘要

对野兔（穴兔）的研究使得在兔免疫球蛋白a位点上检测到了第五个等位基因（a101）。负责A101同种异型特异性的结构在IgG和IgM上均有发现。它们位于重链的Fab片段上。具有A101同种异型特异性的兔子均不具备a系列的两种已知同种异型特异性。育种研究的遗传学证据支持将A101归入a系列，并允许将这种同种异型特异性指定为a101。在法国不同地区的野兔中都发现了a101。它与已知的同种异型没有可检测到的交叉反应。穴兔物种中免疫球蛋白的遗传多态性比该物种家养形式中所描述的要大得多。