Swanson W P
Med Phys. 1980 Mar-Apr;7(2):141-4. doi: 10.1118/1.594774.
The integral dose of accelerator-produced leakage neutrons to patients undergoing high-energy photon therapy is estimated and compared to other sources of integral dose. The leakage neutron component contributes about 5 g rad (1 rad = 10(-2) Gy) for a typical treatment course of 5000 rad. When averaged over a 70-kg tissue volume, the corresponding dose amounts to only 0.36 rad. From this, the risk of inducing fatal malignancies by leakage neutrons is estimated to be about 50 x 10(-6) per year following treatment. This is compared to other risks to which the patient is unavoidably exposed, and it is argued that the unwanted neutrons pose such small additional risk that regulatory intervention is not warranted. This assessment is performed without reference to neutron RBE or quality factor.
估算了接受高能光子治疗的患者所接受的加速器产生的泄漏中子的积分剂量，并与其他积分剂量来源进行了比较。对于典型的5000拉德治疗疗程，泄漏中子成分贡献约5克拉德（1拉德=10^(-2)戈瑞）。当在70千克组织体积上平均时，相应剂量仅为0.36拉德。由此估计，治疗后每年因泄漏中子诱发致命恶性肿瘤的风险约为50×10^(-6)。将此与患者不可避免面临的其他风险进行比较后认为，不需要的中子带来的额外风险极小，因此无需进行监管干预。此评估未参考中子的相对生物效应（RBE）或品质因数。
