Frankel H M, Seitz J, Nolan W
Pflugers Arch. 1980 Mar;384(2):143-7. doi: 10.1007/BF00584430.
This study was undertaken to determine if the decrease in PaCO2 and the concomitant increase in pHa seen during acute (less than 24 h) hyperthermia in all mammals was modified when the hyperthermia was maintained for periods longer than 1 day. Catheters were placed in the descending aortas of anesthetized ewes (pentobarbital, 30 mg/kg, i.v.). After recovery from the surgery, arterial blood samples were drawn daily during a 7 day control period and an 8 day period of continuous hyperthermia. In all animals PaCO2 decreased and remained low during the entire hyperthermic period. PaCO2 (torr) and Tr (degrees C) were inversely correlated by the equation: PaCO2 = - 6.08 Tr + 267.8 (r = 0.84). There was an initial alkalosis with hyperthermia, however pH tended to decrease after the fifth day of hyperthermia. Calculated bicarbonate decreased during hyperthermia. The evidence suggested that when body temperature was increased in sheep, PaCO2 was maintained at a lower value. The low PaCO2 value was maintained independent of changes in pHa.
本研究旨在确定当体温过高持续超过1天时，所有哺乳动物在急性（少于24小时）体温过高期间出现的动脉血二氧化碳分压（PaCO2）降低及动脉血pH值（pHa）相应升高的情况是否会发生改变。将导管插入麻醉母羊（静脉注射戊巴比妥，30毫克/千克）的降主动脉。术后恢复后，在7天的对照期和8天的持续体温过高期内每天采集动脉血样。在所有动物中，PaCO2在整个体温过高期均降低并维持在较低水平。PaCO2（托）与体温（Tr，摄氏度）通过以下方程呈负相关：PaCO2 = - 6.08Tr + 267.8（r = 0.84）。体温过高初期存在碱中毒，但在体温过高第5天后pH值趋于下降。体温过高期间计算得出的碳酸氢盐减少。证据表明，绵羊体温升高时，PaCO2维持在较低值。低PaCO2值的维持与pHa的变化无关。
